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In genetics, transcription factories describe the discrete sites where transcription occurs in the nucleus. They were first discovered in 1993 and have been found to have structures analogous to replication factories, sites where replication also occurs in discrete sites. The factories contain an RNA polymerase (active or inactive) and the necessary transcription factors (activators and repressors) for transcription.〔 〕 Transcription factories containing RNA polymerase II are the most studied but factories can exist for RNA polymerase I and III; the nucleolus being seen as the prototype for transcription factories. It is possible to view them under both light and electron microscropy.〔 〕 The discovery of transcription factories has challenged the original view of how RNA polymerase interacts with the DNA polymer and it is thought that the presence of factories has important effects on gene regulation and nuclear structure. ==Discovery== The first use of the term ‘transcription factory’ was used in 1993 by () and his colleagues who noticed that transcription occurred at discrete sites in the nucleus.〔 〕 This contradicted the original view that transcription occurred at an even distribution throughout the nucleus. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Transcription factories」の詳細全文を読む スポンサード リンク
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